FITC标记的24脱氢胆固醇还原酶抗体
产品名称： FITC标记的24脱氢胆固醇还原酶抗体
英文名称： Anti-Seladin 1/FITC
产品编号： HZ-5390R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Seladin 1/FITC Conjugated antibody
FITC标记的24脱氢胆固醇还原酶抗体
| 英文名称 | Anti-Seladin 1/FITC |
| 中文名称 | FITC标记的24脱氢胆固醇还原酶抗体 |
| 别 名 | Seladin1; Seladin-1; DHCR24; 24 dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; Desmosterol to cholesterol enzyme; Diminuto dwarf1 homolog; SELADIN1; Selective AD indicator 1; Selective Alzheimer's Disease Indicator 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 神经生物学 信号转导 细胞凋亡 转录调节因子 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55/110kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Seladin 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Seladin 1 is highly expressed in brain, adrenal tissues and adrenal tumours, where this enzyme catalyzes the reduction of the delta-24 double bond of sterol intermediates such as desmosterol, during cholesterol biosynthesis. In addition, Seladin 1 has an anti-apoptotic function by reducing caspase 3 activity during oxidative stress-induced apoptosis and protecting cells against amyloid-beta peptide-induced apoptosis. Several studies have identified a reduction in expression levels of this enzyme in brain regions affected by Alzheimer's disease (hippocampus and the subventricular zone). Subunit: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Subcellular Location: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Tissue Specificity: Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. Similarity: Belongs to the FAD-binding oxidoreductase/transferase type 4 family. Contains 1 FAD-binding PCMH-type domain. Database links: Entrez Gene: 1718 Human Entrez Gene: 74754 Mouse Entrez Gene: 298298 Rat Omim: 606418 Human SwissProt: Q15392 Human SwissProt: Q8VCH6 Mouse SwissProt: Q5BQE6 Rat Unigene: 498727 Human Unigene: 133370 Mouse Unigene: 225146 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
SelADIN 1在脑、肾上腺组织和肾上腺肿瘤中高表达，其中该酶催化胆固醇生物合成过程中甾醇中间体（如去氢甾醇）的DelTA-24双键的减少。此外，SelADIN 1通过减少Caspase 3活性在氧化应激诱导的细胞凋亡和保护细胞对抗淀粉样β肽诱导的细胞凋亡中具有抗凋亡作用。一些研究已经证实了这种酶在阿尔茨海默病（海马和脑室下区）影响的脑区的表达水平降低。