FITC标记的成纤维细胞生长因子8抗体
产品名称： FITC标记的成纤维细胞生长因子8抗体
英文名称： Anti-FGF8/FITC
产品编号： HZ-0735R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FGF8/FITC Conjugated antibody
FITC标记的成纤维细胞生长因子8抗体
| 英文名称 | Anti-FGF8/FITC |
| 中文名称 | FITC标记的成纤维细胞生长因子8抗体 |
| 别 名 | AIGF; Androgen induced growth factor; Androgen-induced growth factor; FGF 8; FGF-8; FGF8; Fibroblast growth factor 8 (androgen induced); Fibroblast growth factor 8 precursor; HBGF 8; HBGF-8; HBGF8; FGF8_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FGF8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Keratinocyte growth factor precursor (KGF) (Fibroblast growth factor 8; FGF-8; HBGF-8). Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. [Subcellular location] Secreted. [Tissue specificity] Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos. [Induction] By androgens. Belongs to the heparin-binding growth factors family. Function: Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. Subunit: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Subcellular Location: Secreted. DISEASE: Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous. Similarity: Belongs to the heparin-binding growth factors family. Database links: Entrez Gene: 2253 Human Entrez Gene: 14179 Mouse Entrez Gene: 29349 Rat Omim: 600483 Human SwissProt: P55075 Human SwissProt: P37237 Mouse Unigene: 57710 Human Unigene: 4012 Mouse Unigene: 73565 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 有研究者认为：纤维母细胞生长因子8 FGF8 对癌症具有一定的抑制作用。 早期研究FGF8，认为是自分泌生长因子，它在前列腺癌、乳癌和卵巢癌中常常表现过量表达 (over-expressed)，并与前列腺癌的格里森分数 (Gleason score) 相关联。经过各种细胞和动物模型的实验均支持FGF8在抑制肿瘤形成和肿瘤细胞成活方面的作用。 此外，还有学者认为：FGF8 还在实验中显示出，他有改善因胶原蛋白引发的关节炎性的改变，如：风湿性关节炎和类风湿性关节炎及退行性骨性关节病 |
角质细胞生长因子前体（KGF）（成纤维细胞生长因子8；FGF-8；HBGF-8）。以自分泌的方式刺激细胞的生长。介导荷尔蒙对癌细胞生长的作用。Wnt-1与小鼠乳腺肿瘤病毒诱导小鼠乳腺肿瘤发生的协同作用[亚细胞位置]分泌。[组织特异性]在正常乳腺中不存在，仅在成人睾丸和卵巢和妊娠中期胚胎中检测到。[雄激素诱导]。属于肝素结合生长因子家族。