FITC标记的氨肽酶Q抗体
产品名称： FITC标记的氨肽酶Q抗体
英文名称： Anti-Laeverin/Aminopeptidase Q/FITC
产品编号： HZ-16883R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Laeverin/Aminopeptidase Q/FITC Conjugated antibody
FITC标记的氨肽酶Q抗体
| 英文名称 | Anti-Laeverin/Aminopeptidase Q/FITC |
| 中文名称 | FITC标记的氨肽酶Q抗体 |
| 别 名 | Aminopeptidase Q; AMPQ_HUMAN; AP-Q; APQ; Aqpep; CHL2 antigen; FLJ90650; Laeverin; LVRN; MGC125378; MGC125379; RGD1562779. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 跨膜蛋白 泛素 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 113kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Laeverin/Aminopeptidase Q |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Laeverin is a 990 amino acid member of the peptidase M1 family and contains an HEXXHX18E gluzincin motif and an H(G)AMEN motif. Expressed specifically in placenta on embryo-derived extravillous trophoblasts (EVTs), laeverin localizes to the cell membrane and is a single-pass type II membrane protein. Laeverin binds zinc and functions as a bestatin-sensitive leucine aminopeptidase with a potential role in EVT function. This suggests that laeverin may be involved in human placentation, during which EVTs invade maternal decidua and spiral areteries. More specifically, laeverin may function by regulating the activities of key peptides at the embryo-maternal interface. Laeverin has a broad substrate specificity but exhibits a preference for Leu-4-methylcoumaryl-7-amide. In addition, laeverin can form a homodimer with intermolecular disulfide bond(s). Function: Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C. Subcellular Location: Membrane. Tissue Specificity: Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level). Post-translational modifications: N-glycosylated. Similarity: Belongs to the peptidase M1 family. Database links: Entrez Gene: 206338 Human GenBank: BC045809 Human Omim: 610046 Human SwissProt: Q6Q4G3 Human Unigene: 98288 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
拉维因是肽酶M1家族的990氨基酸成员，包含HxXHX18E葡萄糖锌基序和H（G）阿门基序。赖弗林特异表达于胚胎来源的绒毛外滋养细胞（EVTs）的胎盘，定位于细胞膜，是一种单程II型膜蛋白。拉维因结合锌作为BESTATIN敏感的亮氨酸氨基肽酶，在EVT功能中具有潜在的作用。这表明赖弗林可能与人类胎盘有关，在此期间，EVT侵入母体蜕膜和螺旋区。更具体地说，拉维林可以通过调节胚胎母体界面上的关键肽的活性来发挥作用。拉维因具有广泛的底物特异性，但显示出对LUU-4-甲基香豆素-7-酰胺的偏好。此外，拉维林可以形成具有分子间二硫键（S）的同型二聚体。