FITC标记的蛋氨酸氨肽酶2抗体
产品名称： FITC标记的蛋氨酸氨肽酶2抗体
英文名称： Anti-Methionine Aminopeptidase 2/FITC
产品编号： HZ-18804R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Methionine Aminopeptidase 2/FITC Conjugated antibody
FITC标记的蛋氨酸氨肽酶2抗体
| 英文名称 | Anti-Methionine Aminopeptidase 2/FITC |
| 中文名称 | FITC标记的蛋氨酸氨肽酶2抗体 |
| 别 名 | A930035J23Rik; AI047573; AL024412; Amp2; AMPM2_HUMAN; AU014659,; EIF 2 associated p67 homolog; EIF-2-associated p67; Initiation factor 2 associated 67 kDa glycoprotein; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MAP2; MetAP 2; Metap2; Methionine aminopeptidase 2; Methionyl aminopeptidase 2; MGC102452; MGC127390; MGC53792; MNPEP; p67; p67eIF2; Peptidase M 2; Peptidase M2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 53kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Methionine Aminopeptidase 2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008] Function: Removes the amino-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Subunit: Interacts strongly with the eIF-2 gamma-subunit EIF2S3 By similarity. Binds EIF2S1 at low magnesium concentrations. Post-translational modifications: Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding. Similarity: Belongs to the peptidase M24A family. Database links: Entrez Gene: 10988 Human Entrez Gene: 404150 Cow Entrez Gene: 56307 Mouse Entrez Gene: 64370 Rat Omim: 601870 Human SwissProt: Q3ZC89 Cow SwissProt: P50579 Human SwissProt: O08663 Mouse SwissProt: P38062 Rat Unigene: 444986 Human Unigene: 289329 Mouse Unigene: 1984 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
该基因是甲硫氨酰氨基肽酶家族的成员，编码结合2个钴或锰离子的蛋白质。该蛋白通过保护真核起始因子2的α亚基免受抑制性磷酸化以及从新生蛋白中去除氨基末端蛋氨酸残基而起作用。这种基因的表达增加与各种癌症有关，抗癌药物岩藻霉素和卵黄素通过不可逆地结合到其活性位点来抑制该蛋白。该基因的假基因位于2号染色体上。[ RefSeq，JUL 2008 ]