FITC标记的C型凝集素结构域家族9成员A抗体
产品名称： FITC标记的C型凝集素结构域家族9成员A抗体
英文名称： Anti-CLEC9A/FITC
产品编号： HZ-13620R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CLEC9A/FITC Conjugated antibody
FITC标记的C型凝集素结构域家族9成员A抗体
| 英文名称 | Anti-CLEC9A/FITC |
| 中文名称 | FITC标记的C型凝集素结构域家族9成员A抗体 |
| 别 名 | C type lectin domain family 9, member A; C-type lectin domain family 9 member A; CLC9A_HUMAN; CLEC9A; DNGR1; HEEE9341; PRO34046; UNQ9341. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 干细胞 糖蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLEC9A |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-9A (C-type lectin domain family 9 member A), also known as DNGR1 (dendritic cell natural killer lectin group receptor 1), is a 241 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Expressed in myeloid lineage cells, brain, spleen and thymus, CLEC-9A is a group V C-type lectin-like receptor (CTLR) that acts as an activation receptor. The gene encoding CLEC-9A maps to human chromosome 12p13.2 and mouse chromosome 6 F3. Function: Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. Subcellular Location: Membrane. Tissue Specificity: In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes. Post-translational modifications: N-glycosylated. Similarity: Contains 1 C-type lectin domain. Database links: Entrez Gene: 283420 Human Omim: 612252 Human SwissProt: Q6UXN8 Human Unigene: 531189 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
C型凝集素/C型凝集素样结构域(CTL/CTLD)超家族由多种蛋白组成，它们具有共同的蛋白折叠，具有多种功能，包括细胞信号传导、细胞粘附、糖蛋白周转和免疫应答。CLEC-9A(C型凝集素结构域家族9成员A)，又称DNGR1(树突状细胞天然杀伤凝集素群受体1)，是一种含有一个C型凝集素结构域的241个氨基酸单程II型膜蛋白，属于CTL/CTLD超家族。CLEC-9A是V型C型凝集素样受体（CTLR），在髓系细胞、脑、脾脏和胸腺中均有表达，是一种活化受体。编码CelC-9a基因的人染色体12p132和小鼠染色体6 F