FITC标记的FAM208B蛋白抗体
产品名称： FITC标记的FAM208B蛋白抗体
英文名称： Anti-FAM208B/FITC
产品编号： HZ-14885R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FAM208B/FITC Conjugated antibody
FITC标记的FAM208B蛋白抗体
| 英文名称 | Anti-FAM208B/FITC |
| 中文名称 | FITC标记的FAM208B蛋白抗体 |
| 别 名 | C10orf18; F208B_HUMAN; KIAA2006; Uncharacterized protein C10orf18. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 269kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FAM208B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The FAM20B gene product has been provisionally designated FAM20B pending further characterization. Function: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-o-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. Subcellular Location: Golgi apparatus membrane. Tissue Specificity: Widely expressed. Similarity: Belongs to the FAM20 family. Database links: Entrez Gene: 9917 Human Omim: 611063 Human SwissProt: O75063 Human Unigene: 5737 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
第1号染色体是最大的人类染色体，跨越2亿6000万个碱基对，占人类基因组的8%。1号染色体上约有3000个基因，考虑到基因数量众多，还有大量与1号染色体相关的疾病。值得注意的是，罕见的老化性疾病Hutchinson-Gilford progeria与编码层粘连蛋白A的LMNA基因有关。当有缺陷时，LMNA基因产物可在细胞核内积聚并引起特征性核小泡。迅速增强衰老的机制尚不清楚，是一个继续探索的话题。MutyH基因位于1号染色体上，是家族性腺瘤性息肉病的部分原因。Stutkle综合征、帕金森病、高雪氏病和Aukes综合征也与1号染色体有关。在1q中发现了一个断点，它破坏了DISC1基因并与精神分裂症联系在一起。染色体1异常存在于各种癌症中，包括头颈癌、恶性黑色素瘤和多发性骨髓瘤。FAM20B基因产物已暂时指定为FAM20B，有待进一步鉴定。