FITC标记的α增强子结合蛋白1抗体
产品名称： FITC标记的α增强子结合蛋白1抗体
英文名称： Anti-ATBF1/FITC
产品编号： HZ-11805R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ATBF1/FITC Conjugated antibody
FITC标记的α增强子结合蛋白1抗体
| 产品编号 | bs-11805R-FITC |
| 英文名称 | Anti-ATBF1/FITC |
| 中文名称 | FITC标记的α增强子结合蛋白1抗体 |
| 别 名 | Alpha fetoprotein enhancer binding protein; AT binding transcription factor 1; AT motif binding factor; ATBT; ZFHX3; ZFHX3_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 转录调节因子 锌指蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 404kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ATBF1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: AT-motif binding factor 1 (ATBF1) binds to the AT-rich core sequence element in the human a-fetoprotein enhancer (1). Alternative splicing generates the ATBF1-A and ATBF1-B (2,3). While ATBF1-A contains a 920-amino acid extension at the N-terminus, both ATBF1-A and ATBF1-B contain 4 DNA-binding homeobox domains (2,3). Additionally, ATBF1-A contains 23 zinc finger motifs while ATBF1-B contains 18 zinc finger motifs (1–3). The N-terminal extension unique to ATBF1-A has transcriptional repressor activity (4). In the small intestine, ATBF1-A inhibits expression of the brushborder enzyme aminopeptidase-N through direct binding to the AT motif element (5). Besides functioning in transcription regulation, ATBF1 also functions in ATPase activity (6). ATPase activity associated with ATBF1-A is DNA/RNA-dependent and requires both homeobox domains and zinc finger motifs (6). ATBF1 is highly expressed in spleen and brain tissues (7). The gene encoding human ATBF1 maps to chromosome 16q22.3-q23.1 (8). Function: ATBF1 is a transcription factor that negatively regulates alpha fetoprotein and MYB, transactivates CDKN1A, and may be a tumor suppressor. Loss of ATBF1 is one mechanism that defines the absence of growth control in prostate cancer. Presence of the isoform ABTF1-A is correlated with better prognosis in breast cancer and may also serve as a marker of endocrine responsiveness. Subunit: Interacts with FNBP3 (By similarity). Interacts with PIAS3. Subcellular Location: Nuclear Tissue Specificity: Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 22 C2H2-type zinc fingers. Contains 4 homeobox DNA-binding domains. Database links: UniProtKB/Swiss-Prot: Q15911.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在基序结合因子1（ATBF1）与人甲胎蛋白增强子（1）中AT富含核序列元素结合。选择性剪接产生ATBF1-A和ATBF1-B（2,3）。虽然ATBF1-A在N端含有920个氨基酸延伸，但ATBF1-A和ATBF1-B都含有4个DNA结合同源盒结构域（2,3）。此外，ATBF1-A包含23个锌指基序，而ATBF1-B包含18个锌指基序（1～3）。ATBF1-A特有的N-末端延伸具有转录阻遏活性（4）。在小肠中，ATBF1-A通过直接结合AT模元件（5）抑制刷状酶氨基肽酶N的表达。除了转录调节功能外，ATBF1在ATPase活性（6）中也起作用。与ATBF1-A相关的ATP酶活性是依赖于DNA / RNA的，并且需要同源盒结构域和锌指基序（6）。ATBF1在脾脏和脑组织中高表达（7）。编码人类ATBF1的基因定位于染色体16q22.3-q23.1（8）。