FITC标记的磷酸化乙酰辅酶A羧化酶1ACCα抗体
产品名称： FITC标记的磷酸化乙酰辅酶A羧化酶1ACCα抗体
英文名称： Anti-Phospho-Acetyl CoA Carboxylase(Ser79)/FITC
产品编号： HZ-3039R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-Phospho-Acetyl CoA Carboxylase(Ser79)/FITC Conjugated antibody
FITC标记的磷酸化乙酰辅酶A羧化酶1ACCα抗体
| 英文名称 | Anti-Phospho-Acetyl CoA Carboxylase(Ser79)/FITC |
| 中文名称 | FITC标记的磷酸化乙酰辅酶A羧化酶1ACCα抗体 |
| 别 名 | p-ACACA(Phospho-Ser79); p-ACACA(Phospho S79); Acetyl Coenzyme A Carboxylase alpha (phospho S79); ACAC; ACACA; ACACA; ACACA_HUMAN; ACC alpha; ACC-alpha; ACC1; ACC1; ACCA; Acetyl Coenzyme A; Biotin carboxylase; ACACA_MOUSE; ACACA_RAT；acetyl CoA carboxylase 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 信号转导 转录调节因子 激酶和磷酸酶 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 266kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from mouse Acetyl CoA Carboxylase around the phosphorylation site of Ser79 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC∫ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACC alpha maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC∫ is homologous to that of the ACCå, except for an additional peptide of about 150 amino acids at the N-terminus. Function: Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Subunit: Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. Post-translational modifications: Phosphorylation on Ser-1263 is required for interaction with BRCA1. DISEASE: Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:200350]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth. Similarity: Contains 1 ATP-grasp domain. Contains 1 biotin carboxylation domain. Contains 1 biotinyl-binding domain. Contains 1 carboxyltransferase domain. Database links: Entrez Gene: 107476 Mouse Entrez Gene: 60581 Rat SwissProt: Q5SWU9 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
乙酰辅酶A羧化酶(Acetyl-CoA carboxylase，ACC)是催化乙酰辅酶A羧化合成丙二酰辅酶A(malonyl-CoA)的复杂多功能酶系。运动减少了acetyl CoA carboxylase在人体肌肉中的活动。ACCα(ACC1)是长链脂肪酸生物合成的限速酶，ACC(ACC2)可以控制线粒体脂肪酸的氧化。ACC的这两种亚型控制细胞中脂肪酸的量。ACCα的催化功能通过靶向丝氨酸残基的磷酸化(非活性)和去磷酸化(活性)以及柠檬酸或棕榈酰-CoA的变构转化来调节，后者作为酶的短期调节机制。编码ACCα的基因映射到人类17号染色体并编码ACC的形式，ACC是脂肪组织中的主要ACC。ACC_的催化核心与ACC_相同，除了在N-末端有约150个氨基酸的附加肽外。