FITC标记的G蛋白激活内流钾通道蛋白2抗体
产品名称： FITC标记的G蛋白激活内流钾通道蛋白2抗体
英文名称： Anti-GIRK2/FITC
产品编号： HZ-4214R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-GIRK2/FITC Conjugated antibody
FITC标记的G蛋白激活内流钾通道蛋白2抗体
| 英文名称 | Anti-GIRK2/FITC |
| 中文名称 | FITC标记的G蛋白激活内流钾通道蛋白2抗体 |
| 别 名 | inwardly rectifying subfamily J member 6; Kir3.2; BIR1; G protein activated inward rectifier potassium channel 2; G protein-activated inward rectifier potassium channel 2; GIRK-2; Inward rectifier K(+) channel Kir3.2; IRK6_HUMAN; KATP-2; Kcnj6; Kcnj7; Potassium channel; Potassium channel inwardly rectifying subfamily J member 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 通道蛋白 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GIRK2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Function: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Subunit: Associates with GIRK1 or GIRK4 to form a G-protein-activated heteromultimer pore-forming unit. The resulting inward current is much larger. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily. Database links: Entrez Gene: 3763 Human Entrez Gene: 16522 Mouse Entrez Gene: 25743 Rat Omim: 600877 Human SwissProt: P48051 Human SwissProt: P48542 Mouse SwissProt: P48550 Rat Unigene: 626242 Human Unigene: 658533 Human Unigene: 741904 Human Unigene: 328720 Mouse Unigene: 10185 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该钾通道可能参与通过G蛋白偶联受体作用的葡萄糖和/或神经递质调节胰岛素分泌。向内整流钾通道的特征是允许钾进入细胞而不是流出细胞的更大趋势。它们的电压依赖性受细胞外钾浓度的调节；当外部钾升高时，通道开口的电压范围转移到更多正电压。内部整流主要是由于内部镁阻挡外向电流。